Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor
نویسندگان
چکیده
منابع مشابه
Novel adenovirus vectors 'capsid-displaying' a human complement inhibitor.
Adenovirus (Ad) vectors are currently the most commonly utilized gene transfer vectors in humans worldwide. Unfortunately, upon contact with the circulatory system, Ads induce several, innate, complement-dependent toxicities that limit the full potential for Ad-based gene transfer applications. Therefore, we have constructed several novel Ad5-based vectors, 'capsid-displaying' as fiber or pIX f...
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Adenoviruses infect a wide range of vertebrates including humans. Their icosahedral capsids are composed of three major proteins: the trimeric hexon forms the facets and the penton, a noncovalent complex of the pentameric penton base and trimeric fibre proteins, is located at the 12 capsid vertices. Several proteins (IIIa, VI, VIII and IX) stabilise the capsid. We have obtained a 10 A resolutio...
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The complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and membrane regulators. We describe complement C2 receptor inhibitor trispanning (CRIT), a novel human complement regulatory receptor, expressed on hemopoietic cells and a wide range of tissues throughout the body. CRIT is present in human pa...
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Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids with microglia-specific transduction properties, we initially screened the most commonly used seroty...
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Smith, Kendall O. (Baylor University College of Medicine, Houston, Tex.), Warren D. Gehle, and Melvin D. Trousdale. Architecture of the adenovirus capsid. J. Bacteriol. 90:254-261. 1965.-The capsids of adenovirus type 2 were fragmented by treatment with low concentrations of sodium lauryl sulfate. The clusters of capsomeres resulting from this treatment displayed characteristic patterns. Some o...
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ژورنال
عنوان ژورنال: Journal of Innate Immunity
سال: 2010
ISSN: 1662-811X,1662-8128
DOI: 10.1159/000284368